DISTRIBUTION OF ENDOTRACHEALLY INSTILLED SURFACTANT PROTEIN SP-C IN LUNG-LAVAGED RABBITS

被引：9
作者：
OETOMO, SB
DELEY, L
CURSTEDT, T
TERHAAR, JG
SCHOOTS, C
WILDEVUUR, CRH
OKKEN, A
机构：
[1] STATE UNIV GRONINGEN, DEPT PEDIAT, DIV NEONATOL, GRONINGEN, NETHERLANDS
[2] STATE UNIV GRONINGEN, DEPT CLIN IMMUNOL, GRONINGEN, NETHERLANDS
[3] STATE UNIV GRONINGEN, DEPT PATHOL, GRONINGEN, NETHERLANDS
[4] STATE UNIV GRONINGEN, DEPT THORAC SURG, DIV RES, GRONINGEN, NETHERLANDS
[5] KAROLINSKA HOSP, DEPT CLIN CHEM, S-10401 STOCKHOLM 60, SWEDEN
来源：
PEDIATRIC RESEARCH | 1991年 / 29卷 / 02期
关键词：
D O I：
10.1203/00006450-199102000-00015
中图分类号：
R72 [儿科学];
学科分类号：
100202 ;
摘要：
In lung-lavaged surfactant-deficient rabbits (n = 6) requiring artificial ventilation, porcine surfactant was instilled endotracheally. This resulted in improvement of lung function so that the animals could be weaned off artificial ventilation. The animals were killed 4 1/2 h after surfactant administration and the porcine surfactant protein was localized in the lung with a MAb. We found surfactant protein in all lobes of the lung but the distribution was not homogeneous. Surfactant protein C was found in less than 15% of the alveolar spaces and in less than 1% of the bronchi.
引用
收藏
页码：178 / 181
页数：4
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