SERUM-LIPID AND LIPOPROTEIN LEVELS IN THE SENESCENCE-ACCELERATED MOUSE

After 2-4 months of age, accelerated senescence-prone mice showed a higher level of serum triglycerides and lower levels of total cholesterol and phospholipids than accelerated senescence-resistant mice. At 2-4 months of age, the former strain showed higher levels of very low density lipoprotein and low density lipoprotein and a lower level of high density lipoprotein-cholesterol than the latter strain. The serum lipid peroxide level per mg of serum lipids was higher in the former than in the latter. These results indicate that a disorder in the metabolism of lipids and lipoproteins occurs concomitantly with the increase in serum lipid peroxide level in this animal model of accelerated aging.