LAMININ, FIBRONECTIN, AND GOODPASTURE ANTIGEN-DETECTION IN PATIENTS WITH ALPORTS-SYNDROME

被引：3

作者：

BASTAJOVANOVIC, G ^{[1
]}

SAVIN, M ^{[1
]}

JOVANOVIC, AZ ^{[1
]}

VELJOVIC, R ^{[1
]}

SINDJIC, M ^{[1
]}

机构：

[1] UNIV CLIN CTR BELGRADE, SCH MED, INST UROL & NEPHROL, BELGRADE, YUGOSLAVIA

来源：

RENAL FAILURE | 1993年 / 15卷 / 04期

关键词：

D O I：

10.3109/08860229309054965

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Indirect immunofluorescence study with laminin and fibronectin monoclonal antibodies on paraffin sections, as well as with serum from a patient with Goodpasture's syndrome with high titer of autoantibodies that recognize the antigenic determinants in human glomerular and tubular basement membrane, was performed on 14 patients with Alport's syndrome and 5 specimens of normal renal tissue obtained from donors in cases of renal transplantation (control group). We found no binding of Goodpasture antigen to glomerular and distal tubular basement membranes in renal biopsy tissue from all 14 patients with Alport's syndrome. In contrast, there was bright linear fluorescence of Goodpasture antigen on glomerular and tubular basement membranes of normal renal material. There was no difference in laminin and fibronectin binding in patients with Alport's syndrome and controls. In all the cases binding was strongly positive. These results suggest an abnormality or absence of immunoreactive autoantigen in the glomerular and distal tubular basement membrane in patients with Alport's syndrome. Therefore, Goodpasture antigen detection could be an important diagnostic method in early stages of Alport's syndrome when characteristic morphological changes are not yet developed.

引用

页码：503 / 508

页数：6

共 17 条

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