Decreased blood-brain barrier expression of P-glycoprotein in Alzheimer's disease: impact on pathogenesis and brain access of therapeutic agents

被引：7
作者：
Nicolazzo, Joseph A. [1 ]
Banks, William A. [2 ,3 ]
机构：
[1] Monash Univ, Monash Inst Pharmaceut Sci, Drug Delivery Disposit & Dynam, 381 Royal Parade, Parkville, Vic 3052, Australia
[2] Vet Affairs Puget Sound Hlth Care Syst, GRECC, Seattle, WA USA
[3] Univ Washington, Sch Med, Dept Internal Med, Div Gerontol & Geriatr Med, Seattle, WA 98195 USA
来源：
THERAPEUTIC DELIVERY | 2011年 / 2卷 / 07期
关键词：
beta-amyloid; Alzheimer's disease; blood-brain barrier; CNS; efflux transporter; P-glycoprotein;
D O I：
10.4155/TDE.11.65
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
It is likely that the brain uptake of other P-gp substrates such as digoxin, loperamide and quinidine may also be enhanced in AD, potentially placing AD patients at risk of enhanced exposure...
引用
收藏
页码：841 / 844
页数：4
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