Hydrogels as drug-delivery platforms: physicochemical barriers and solutions

被引：10

作者：

Alkayyali, Lamees B. ^{[1
]}

Abu-Diak, Osama A. ^{[1
]}

Andrews, Gavin P. ^{[1
]}

Jones, David S. ^{[1
]}

机构：

[1] Queens Univ Belfast, Sch Pharm, Drug Delivery & Biomat Grp, Ctr Med Biol, 97 Lisburn Rd, Belfast BT9 7BL, Antrim, North Ireland

来源：

THERAPEUTIC DELIVERY | 2012年 / 3卷 / 06期

关键词：

D O I：

10.4155/TDE.12.48

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The properties of hydrogels, in particular their high biocompatibility and water sorption uptake, make hydrogels very attractive in drug delivery and biomedical devices. These favorable features of hydrogels are compromised by certain structural limitations such as those associated with their low mechanical strength in the swollen state. This review highlights the most important challenges that may seriously affect the practical implementation of hydrogels in clinical practice and the solutions that may be applied to overcome these limitations.

引用

页码：775 / 786

页数：12

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