A meta-analysis to determine the effect of pre-injury warfarin on mortality in trauma patients

被引：2

作者：

Batchelor, John S. ^{[1
]}

Ahmed, Shariq ^{[1
]}

机构：

[1] Cent Manchester Fdn Trust, Dept Emergency Med, Manchester, Lancs, England

来源：

TRAUMA-ENGLAND | 2014年 / 16卷 / 02期

关键词：

Trauma; warfarin; anticoagulation; mortality; meta-analysis; adults;

D O I：

10.1177/1460408614525731

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

The aim of this meta-analysis was to determine the effect and magnitude of effect of pre-injury warfarin on trauma patients. Studies comparing all trauma patients (nb. not head injury patients only) on pre-injury warfarin to all trauma patients not on pre-injury warfarin were included in the meta-analysis. The search was performed using Medline via the PubMed interface; no limits were placed on the language. Ten papers were found to be suitable for the meta-analysis. There were two case control studies and eight retrospective cohort (nested case control) studies. Significant heterogeneity was present as measured by the Q test (Q value = 126.366 df = 9, p = 0.000) and also the I-2 test (I-2 = 92.878). The preferred model for this meta-analysis was considered to be the Fixed effect model which produced a common OR 1.952 (95% CI; 1.888-2.018, p = 0.000). The results of this meta-analysis show that pre-injury warfarin does increase mortality in trauma patients by an odds ratio of nearly two.

引用

页码：108 / 113

页数：6

共 12 条

[1] A meta-analysis to determine the effect of anticoagulation on mortality in patients with blunt head trauma [J].

Batchelor, John Stephen ;

Grayson, Alan .

BRITISH JOURNAL OF NEUROSURGERY, 2012, 26 (04) :525-530

[2] Impact of preinjury warfarin and antiplatelet agents on outcomes of trauma patients [J].

Bonville, Daniel J. ;

Ata, Ashar ;

Jahraus, Carrie B. ;

Arnold-Lloyd, Travis ;

Salem, Leon ;

Rosati, Carl ;

Stain, Steven C. .

SURGERY, 2011, 150 (04) :861-867

[3] Prevalence and Implications of Preinjury Warfarin Use An Analysis of the National Trauma Databank [J].

Dossett, Lesly A. ;

Riesel, Johanna N. ;

Griffin, Marie R. ;

Cotton, Bryan A. .

ARCHIVES OF SURGERY, 2011, 146 (05) :565-570

[4] The Relationship Between Mortality and Preexisting Cardiac Disease in 5,971 Trauma Patients [J].

Ferraris, Victor A. ;

Ferraris, Suellen P. ;

Saha, Sibu P. .

JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE, 2010, 69 (03) :645-652

[5] Preinjury Warfarin Worsens Outcome in Elderly Patients Who Fall From Standing [J].

Howard, Jerry Lee, II ;

Cipolle, Mark D. ;

Horvat, Sarah A. ;

Sabella, Victoria M. ;

Reed, James F., III ;

Fulda, Gerard ;

Tinkoff, Glen ;

Pasquale, Michael D. .

JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE, 2009, 66 (06) :1518-1524

[6] Impact of preinjury warfarin use in elderly trauma patients [J].

Kennedy, DM ;

Cipolle, MD ;

Pasquale, MD ;

Wasser, T .

JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE, 2000, 48 (03) :451-453

[7] Antiplatelet and Anticoagulation Therapies Do Not Increase Mortality in the Absence of Traumatic Brain Injury [J].

Ott, Mickey Meilinger ;

Eriksson, Evert ;

Vanderkolk, Wayne ;

Christianson, David ;

Davis, Alan ;

Scholten, Donald .

JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE, 2010, 68 (03) :560-563

[8] The Impact of Select Chronic Diseases on Outcomes after Trauma: A Study from the National Trauma Data Bank [J].

Patel, Madhukar S. ;

Malinoski, Darren J. ;

Nguyen, Xuan-Mai T. ;

Hoyt, David B. .

JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS, 2011, 212 (01) :96-104

[9] Use of long-term anticoagulation is associated with traumatic intracranial hemorrhage and subsequent mortality in elderly patients hospitalized after falls: Analysis of the New York state administrative database [J].

Pieracci, Fredric M. ;

Eachempati, Soumitra R. ;

Shou, Jian ;

Hydo, Lynn J. ;

Barie, Philip S. .

JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE, 2007, 63 (03) :519-524

[10] Meta-analysis of observational studies in epidemiology - A proposal for reporting [J].

Stroup, DF ;

Berlin, JA ;

Morton, SC ;

Olkin, I ;

Williamson, GD ;

Rennie, D ;

Moher, D ;

Becker, BJ ;

Sipe, TA ;

Thacker, SB .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2000, 283 (15) :2008-2012

← 1 2 →