INVITRO ACTIVITY OF CIPROFLOXACIN IN COMBINATION WITH CEFTAZIDIME, AZTREONAM, AND AZLOCILLIN AGAINST MULTIRESISTANT ISOLATES OF PSEUDOMONAS-AERUGINOSA

被引：33

作者：

BUSTAMANTE, CI ^{[1
]}

WHARTON, RC ^{[1
]}

WADE, JC ^{[1
]}

机构：

[1] UNIV MARYLAND,CTR CANC,INFECT DIS & MICROBIOL SECT,BALTIMORE,MD 21201

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1990年 / 34卷 / 09期

关键词：

D O I：

10.1128/AAC.34.9.1814

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The combination of ciprofloxacin plus ceftazidime, ciprofloxacin plus aztreonam, and ciprofloxacin plus azlocillin were evaluated for the presence of synergy against multiresistant isolates of Pseudomonas aeruginosa. The frequency of synergy was dependent on antibiotic susceptibilities. If the organism was resistant to ciprofloxacin, synergy was observed in more than 50% of the isolates; however, if the organism was resistant to the beta-lactam (with the exception of ceftazadime), synergy was generally observed in less than 10% of the isolates. Antagonism was not observed with any of the combinations. These results may be helpful in making clinical decisions in treating P. aeruginosa infections.

引用

页码：1814 / 1815

页数：2

共 8 条

[1] SYNERGISM OF THE COMBINATIONS OF IMIPENEM PLUS CIPROFLOXACIN AND IMIPENEM PLUS AMIKACIN AGAINST PSEUDOMONAS-AERUGINOSA AND OTHER BACTERIAL PATHOGENS [J].

BUSTAMANTE, CI ;

DRUSANO, GL ;

WHARTON, RC ;

WADE, JC .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1987, 31 (04) :632-634

[2] ANTIMICROBIAL ACTIVITY OF CIPROFLOXACIN AGAINST PSEUDOMONAS-AERUGINOSA, ESCHERICHIA-COLI, AND STAPHYLOCOCCUS-AUREUS DETERMINED BY THE KILLING CURVE METHOD - ANTIBIOTIC COMPARISONS AND SYNERGISTIC INTERACTIONS [J].

CHALKLEY, LJ ;

KOORNHOF, HJ .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1985, 28 (02) :331-342

[3] SYNERGY OF IMIPENEM - A NOVEL CARBAPENEM, AND RIFAMPIN AND CIPROFLOXACIN AGAINST PSEUDOMONAS-AERUGINOSA, SERRATIA-MARCESCENS AND ENTEROBACTER SPECIES [J].

CHIN, NX ;

NEU, HC .

CHEMOTHERAPY, 1987, 33 (03) :183-188

[4]

DAVIES GSR, 1985, J ANTIMICROB CHEMOTH, V16, P713

[5] CIPROFLOXACIN INTERACTIONS WITH IMIPENEM AND AMIKACIN AGAINST MULTIRESISTANT PSEUDOMONAS-AERUGINOSA [J].

GIAMARELLOU, H ;

PETRIKKOS, G .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1987, 31 (06) :959-961

[6]

HALLER I, 1985, 1ST P INT CIPR WORKS, P50

[7]

MOODY JA, 1987, AM J MED, V82, P44

[8]

NEU HC, 1989, REV INFECT DIS S5, V2, pS1025

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