D-3,4-CYCLOPROPYLGLUTAMATE ISOMERS AS NMDA RECEPTOR LIGANDS - SYNTHESIS AND ENANTIOSELECTIVE ACTIVITY

被引：56

作者：

PELLICCIARI, R

NATALINI, B

MARINOZZI, M

MONAHAN, JB

SNYDER, JP

机构：

[1] GD SEARLE & CO,SEARLE R&D DIV,ST LOUIS,MO

[2] GD SEARLE & CO,SEARLE R&D DIV,SKOKIE,IL 60077

来源：

TETRAHEDRON LETTERS | 1990年 / 31卷 / 01期

关键词：

D O I：

10.1016/S0040-4039(00)94355-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Dirhodium(II) tetraacetate catalyzed decomposition of ethyl diazoacetate in the presence of D-Cbz-vinylglycine methyl ester (11) afforded a mixture of the cyclopropyl esters D-CGA A-D (13) from which the corresponding 2R-acids 7-10 were obtained and their absolute configurations assigned. The (2R,3S,4R) α-(carboxycyclopropyl)glycine (D-CGA C, 9 resulted to be the most potent and selective among the NMDA receptor ligands yet reported. © 1990.

引用

页码：139 / 142

页数：4

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