The Expression of Ezrin and Its Significance in Non-small Cell Lung Cancer

被引：1
作者：
Ma Lan [1 ]
Wu Hao [1 ]
Sun Jing [1 ]
Liu Lian-ke [1 ]
机构：
[1] Nanjing Med Univ, Affiliated Hosp 1, Dept Oncol, Nanjing 210029, Jiangsu, Peoples R China
来源：
JOURNAL OF INTERNATIONAL TRANSLATIONAL MEDICINE | 2014年 / 2卷 / 03期
关键词：
Lung cancer; Ezrin; Metastasis; Prognosis;
D O I：
10.11910/2227-6394.2014.02.03.12
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Objective: To explore the expression of ezrin and its significance in non-small cell lung cancer (NSCLC). Methods: The expression of ezrin in 81 NSCLC patients were examined by immunohistochemical staining Envision method, and its relationships with the clinopathologic features and other indexes were analyzed. Results: The high expression rate of ezrin in NSCLC was 59.26% (48/81) and significantly correlated with lymph node metastasis (P < 0.05), but not associated with gender, histologic subtype, differentiation, TNM stages or smoking. The K-M survival analysis demonstrated that patients with the over-expression of ezrin were obviously poorer than those with low-expression of ezrin (P < 0.05). Conclusion: The expression of ezrin may be associated with metastasis of NSCLC, can be as an important marker for evaluating the prognosis of NSCLC patients.
引用
收藏
页码：408 / 412
页数：5
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