The Expression of Ezrin and Its Significance in Non-small Cell Lung Cancer

Objective: To explore the expression of ezrin and its significance in non-small cell lung cancer (NSCLC). Methods: The expression of ezrin in 81 NSCLC patients were examined by immunohistochemical staining Envision method, and its relationships with the clinopathologic features and other indexes were analyzed. Results: The high expression rate of ezrin in NSCLC was 59.26% (48/81) and significantly correlated with lymph node metastasis (P < 0.05), but not associated with gender, histologic subtype, differentiation, TNM stages or smoking. The K-M survival analysis demonstrated that patients with the over-expression of ezrin were obviously poorer than those with low-expression of ezrin (P < 0.05). Conclusion: The expression of ezrin may be associated with metastasis of NSCLC, can be as an important marker for evaluating the prognosis of NSCLC patients.