VASOACTIVE EICOSANOIDS - SYNTHESIS OF 12,20-DIHYDROXYEICOSA-5(Z),8(Z),10(E),14(Z)-TETRAENOIC ACID VIA A NOVEL CHIRAL BIS-LACTOL

被引：2

作者：

FALCK, JR ^{[1
]}

CHAUHAN, K ^{[1
]}

ROSOLOWSKY, M ^{[1
]}

CAMPBELL, WB ^{[1
]}

机构：

[1] UNIV TEXAS, SW MED CTR, DEPT PHARMACOL, DALLAS, TX 75235 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1994年 / 4卷 / 17期

关键词：

D O I：

10.1016/S0960-894X(01)80112-8

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The type IIB eicosanoids, 12(R),20- and 12(S),20-dihydroxyeicosatetraenoic acid (DiHETE), were conveniently synthesized utilizing a carbohydrate-derived bis-lactol as a differentiated 4-hydroxyhex-2(E)-enedial chiron. 12(S),20-DiHETE, but not the 12(R)-isomer, induced vasodilation in precontracted canine arteries.

引用

页码：2113 / 2116

页数：4

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