Brain stem energy metabolism response to acute hypoxia in anaesthetized rats: A P-31 NMR study

被引：0
作者：
Pierard, C
Champagnat, J
DenavitSaubie, M
Gillet, B
Beloeil, JC
Guezennec, CY
Barrere, B
Peres, M
机构：
[1] CNRS,LAB RMN BIOL,F-91198 GIF SUR YVETTE,FRANCE
[2] INST ALFRED FESSARD,F-91198 GIF SUR YVETTE,FRANCE
来源：
NEUROREPORT | 1995年 / 7卷 / 01期
关键词：
brain stem; hypoxia; NMR spectroscopy; phosphocreatine; ATP; respiratory rhythm;
D O I：
暂无
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
MAMMALS react to acute hypoxia with an initial augmentation and a secondary depression of the respiratory rhythm generated by brain stem neuronal networks. To investigate the cytosolic level of energy rich phosphorus metabolites during these responses, we developed P-31 nuclear magnetic resonance spectroscopy of the brain stem. Moderate hypoxia (p(a)O(2) = 40 mmHg, 2 min) caused a reversible 62 +/- 15% respiratory rhythm depression and decreased cytosolic phosphocreatine levels by 43 +/- 11% (p < 0.01, n = 7) without affecting adenosine triphosphate levels. Cellular metabolic depletion therefore contributes to the brain stem response to hypoxia, and appears to reflect adaptive mechanisms to limited oxygen availability in the brain stem.
引用
收藏
页码：281 / 285
页数：5
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