PRECONTRACTION WITH HISTAMINE AND U46619 UNMASKS A 5-HT1-LIKE RECEPTOR IN RABBIT RENAL-ARTERY

被引：24

作者：

CHOPPIN, A ^{[1
]}

OCONNOR, SE ^{[1
]}

机构：

[1] SYNTHELABO RECH LERS,DEPT BIOL,31 AVE PAUL VAILLANTCOUTURIER,F-92225 BAGNEUX,FRANCE

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1993年 / 231卷 / 03期

关键词：

VASCULAR 5-HT1-LIKE RECEPTORS; 5-HT; (5-HYDROXYTRYPTAMINE; SEROTONIN); 5-CARBOXAMIDOTRYPTAMINE; (EFFECT OF PRECONTRACTION);

D O I：

10.1016/0014-2999(93)90126-3

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Rabbit renal arteries were virtually unresponsive to 5-hydroxytryptamine (5-HT) and 5-carboxamidotryptamine (5-CT) under control conditions (including the presence of ketanserin 10(-6) M). However, both agents produced prominent contractions over the range 10(-9)-10(-5) M in tissues pre-contracted with threshold concentrations of either histamine or U46619. These responses were considered to be mediated by activation of 5-HT1-like receptors based on the potency order 5-CT less-than-or-equal-to 5-HT and the sensitivity of agonist responses to antagonism by methiothepin (10(-7) M). Pre-contraction with different types of vasoconstrictor can therefore unmask functional 5-HT1-like receptors in rabbit renal artery.

引用

页码：469 / 472

页数：4

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