A 1H-NMR STUDY OF THE SOLUTION CONFORMATION OF CYCLO(GRGDSPA) - CONFORMATIONAL EFFECTS ON THE PHYSIOLOGICAL-ACTIVITY

被引：18
|
作者：
MIZUTANI, R
SHIMADA, I
UENO, Y
YODA, M
KUMAGAI, H
ARATA, Y
机构：
[1] UNIV TOKYO,FAC PHARMACEUT SCI,TOKYO 113,JAPAN
[2] ASAHI GLASS CO LTD,RES CTR,KANAGAWA KU,YOKOHAMA,KANAGAWA 221,JAPAN
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1992年 / 182卷 / 02期
关键词：
D O I：
10.1016/0006-291X(92)91826-C
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Solution conformations of cyclo(GRGDSPA) have been analyzed by the use of two-dimensional proton nuclear magnetic resonance spectroscopy and the dynamical simulated annealing calculation. It has been shown that the RGDS segment in cyclo(GRGDSPA) takes a β-turn conformation. We have concluded that this β-turn conformation is essential for the physiological activity of cyclo(GRGDSPA). © 1992.
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页码：966 / 973
页数：8
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