REACTIONS OF COPPER(II)-OLIGOPEPTIDE COMPLEXES WITH HYDROGEN-PEROXIDE - EFFECTS OF BIOLOGICAL REDUCTANTS

被引：24

作者：

UEDA, JI ^{[1
]}

SHIMAZU, Y ^{[1
]}

OZAWA, T ^{[1
]}

机构：

[1] NATL INST RADIOL SCI,INAGE KU,CHIBA 263,JAPAN

来源：

FREE RADICAL BIOLOGY AND MEDICINE | 1995年 / 18卷 / 05期

关键词：

(OH)-O-. RADICALS; COPPER ION; HISTIDINE; OLIGOPEPTIDES; DNA STRAND BREAKS; ASCORBIC ACID; GLUTATHIONE; CYSTEINE; FREE RADICALS;

D O I：

10.1016/0891-5849(94)00213-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cu(II) complexes with oligopeptides containing histidyl residue in the second or third position could scarcely activate hydrogen peroxide (H2O2), but they could activate H2O2 to yield hydroxyl radical ((OH)-O-.) in the presence of biological reductants such as cysteine and ascorbic acid. Further, DNA single strand breakage was also observed during the reactions of Cu(II)-glycylglycylhistidylglycine (GGHG) with H2O2 in the presence of same biological reductants.

引用

页码：929 / 933

页数：5

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