REVERSIBLE INHIBITION BY INTERFERON-ALPHA AND INTERFERON-BETA OF I-125 INCORPORATION AND THYROID-HORMONE RELEASE BY HUMAN THYROID-FOLLICLES IN-VITRO

被引：55

作者：

YAMAZAKI, K

KANAJI, Y

SHIZUME, K

YAMAKAWA, Y

DEMURA, H

KANAJI, Y

OBARA, T

SATO, K

机构：

[1] TOKYO WOMENS MED COLL, INST CLIN ENDOCRINOL, SHINJUKU KU, TOKYO, TOKYO 162, JAPAN

[2] KANAJI HOSP, KITA KU, TOKYO, TOKYO 114, JAPAN

[3] RES INST GROWTH SCI, SHINJUKU KU, TOKYO, TOKYO 162, JAPAN

来源：

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM | 1993年 / 77卷 / 05期

关键词：

D O I：

10.1210/jc.77.5.1439

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

When interferons (IFN-alpha-2a, IFN-alpha-2b, natural IFN-alpha and IFN-beta) were cultured with human thyroid follicles, each IFN inhibited TSH-induced thyroid function (I-125 incorporation and release of I-125-T-4) in a concentration-dependent manner. The minimal inhibitory effect was exerted at 1 - 10 U/ml. However, the inhibitory effect was reversible, and no inhibitory effect was detected when IFNs were removed from the medium within 12 h. These in vitro findings suggest that each IFN directly inhibits human thyroid function at clinically attainable levels. However, since the inhibitory effect was reversible, IFN therapy would provoke only subtle thyroid dysfunction in a majority of patients without preexisting thyroid autoimmunity.

引用

收藏

页码：1439 / 1441

页数：3

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