CATALYTIC ENANTIOSELECTIVE DIELS-ALDER ADDITION TO FURAN PROVIDES A DIRECT SYNTHETIC ROUTE TO MANY CHIRAL NATURAL-PRODUCTS

被引：147

作者：

COREY, EJ

LOH, TP

机构：

[1] Department of Chemistry, Harvard University, Cambridge

来源：

TETRAHEDRON LETTERS | 1993年 / 34卷 / 25期

关键词：

D O I：

10.1016/S0040-4039(00)60594-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An oxazaborolidine derived from N-tosyl (alphaS,betaR)-beta-methyltryptophan (1)catalyzes the Diels-Alder reaction of 2-bromoacrolein and furan with 96:4 enantioselectivity, leading to an efficient synthesis of numerous chiral 7-oxabicyclo[2.2.1]heptene derivatives.

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页码：3979 / 3982

页数：4

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