TREATMENT OF SICKLE-CELL-ANEMIA WITH 5-AZACYTIDINE RESULTS IN INCREASED FETAL HEMOGLOBIN PRODUCTION AND IS ASSOCIATED WITH NONRANDOM HYPOMETHYLATION OF DNA AROUND THE GAMMA-DELTA-BETA-GLOBIN GENE-COMPLEX

被引：262
作者：
CHARACHE, S
DOVER, G
SMITH, K
TALBOT, CC
MOYER, M
BOYER, S
机构：
[1] JOHNS HOPKINS UNIV,SCH MED,DEPT PEDIAT,BALTIMORE,MD 21205
[2] JOHNS HOPKINS UNIV,SCH MED,DEPT LAB MED,BALTIMORE,MD 21205
[3] HOWARD HUGHES MED INST,HUMAN BIOCHEM GENET LAB,BALTIMORE,MD 21205
来源：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES | 1983年 / 80卷 / 15期
关键词：
D O I：
10.1073/pnas.80.15.4842
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
引用
收藏
页码：4842 / 4846
页数：5
相关论文
共 38 条
[1]  
BENEDICT WF, 1977, CANCER RES, V37, P2202
[2]   HEMOGLOBIN INTERACTION - MODIFICATION OF SOLID PHASE COMPOSITION IN SICKLING PHENOMENON [J].
BERTLES, JF ;
RABINOWITZ, R ;
DOBLER, J .
SCIENCE, 1970, 169 (3943) :375-+
[3]   LOSS OF RDNA METHYLATION ACCOMPANIES THE ONSET OF RIBOSOMAL GENE ACTIVITY IN EARLY DEVELOPMENT OF X-LAEVIS [J].
BIRD, A ;
TAGGART, M ;
MACLEOD, D .
CELL, 1981, 26 (03) :381-390
[4]   POST-SYNTHETIC DEAMIDATION OF HEMOGLOBIN PROVIDENCE (BETA-82 LYS-]ASN ASP) AND ITS EFFECT ON OXYGEN-TRANSPORT [J].
CHARACHE, S ;
FOX, J ;
MCCURDY, P ;
KAZAZIAN, H ;
WINSLOW, R .
JOURNAL OF CLINICAL INVESTIGATION, 1977, 59 (04) :652-658
[5]  
CHARACHE S, 1981, BLOOD, V58, P892
[6]   TOXIC-THERAPEUTIC RATIO OF SODIUM CYANATE [J].
CHARACHE, S ;
DUFFY, TP ;
JANDER, N ;
SCOTT, JC ;
BEDINE, M ;
MORRELL, R .
ARCHIVES OF INTERNAL MEDICINE, 1975, 135 (08) :1043-1047
[7]   EXPRESSION OF TRANSFERRED THYMIDINE KINASE GENES IS CONTROLLED BY METHYLATION [J].
CHRISTY, B ;
SCANGOS, G .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1982, 79 (20) :6299-6303
[8]   DNA METHYLATION CONTROLS THE INDUCIBILITY OF THE MOUSE METALLOTHIONEIN-I GENE IN LYMPHOID-CELLS [J].
COMPERE, SJ ;
PALMITER, RD .
CELL, 1981, 25 (01) :233-240
[9]   FUNCTIONAL STRIATED-MUSCLE CELLS FROM NON-MYOBLAST PRECURSORS FOLLOWING 5-AZACYTIDINE TREATMENT [J].
CONSTANTINIDES, PG ;
JONES, PA ;
GEVERS, W .
NATURE, 1977, 267 (5609) :364-366
[10]  
CREUSOT F, 1982, J BIOL CHEM, V257, P2041
1234