IMMUNOREGULATORY PROPERTIES OF IL-13 - ITS POTENTIAL ROLE IN ATOPIC DISEASE

被引：74

作者：

DEVRIES, JE ^{[1
]}

ZURAWSKI, G ^{[1
]}

机构：

[1] DNAX RES INST MOLEC & CELLULAR BIOL INC, DEPT HUMAN IMMUNOL & MOLEC BIOL, PALO ALTO, CA 94304 USA

来源：

INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY | 1995年 / 106卷 / 03期

关键词：

IL-13; IGE; ALLERGY; IL-4; AND; 1L-13; RECEPTOR ANTAGONIST;

D O I：

10.1159/000236842

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

IL-13 is a relatively novel cytokine produced by activated T cells. IL-13 inhibits the production of proinflammatory cytokines and chemokines by activated monocytes, induces B cell proliferation and differentiation, including IgE production, and the expression of certain adhesion molecules on endothelial cells. All these biological properties of IL-13 are shared with IL-4, but in contrast to IL-4, IL-13 does not act on T cells. In this review, the similarities in structure and biological function of IL-13 and IL-4 and the commonalities of their receptors are summarized. The potential role of IL-13 in allergic responses is briefly discussed.

引用

页码：175 / 179

页数：5

共 27 条

[1] AN INTERLEUKIN-4 (IL-4) MUTANT PROTEIN INHIBITS BOTH IL-4 OR IL-13-INDUCED HUMAN IMMUNOGLOBULIN-G4 (IGG4) AND IGE SYNTHESIS AND B-CELL PROLIFERATION - SUPPORT FOR A COMMON COMPONENT SHARED BY IL-4 AND IL-13 RECEPTORS [J].