THE SYNTHESIS OF 2,2-BIS(TRIFLUOROMETHYL)BENZOPYRAN DERIVATIVES - A NEW ROUTE TO AN IMPORTANT CLASS OF POTASSIUM CHANNEL ACTIVATORS

被引：14

作者：

FENWICK, AE

机构：

[1] SmithKline Beecham Pharmaceuticals, Epsom, Surrey KT18 5XQ England, Great Burgh, Yew Tree Bottom Rd

来源：

TETRAHEDRON LETTERS | 1993年 / 34卷 / 11期

关键词：

BENZOPYRAN; INTRAMOLECULAR CYCLIZATION; POTASSIUM CHANNEL ACTIVATOR;

D O I：

10.1016/S0040-4039(00)60787-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new route to an important class of biologically active benzopyrans was developed via an intramolecular cyclisation and cis diol formation.

引用

页码：1815 / 1818

页数：4

共 6 条

[1] SYNTHESIS AND ANTIHYPERTENSIVE ACTIVITY OF 4-(CYCLIC AMIDO)-2H-1-BENZOPYRANS [J].

ASHWOOD, VA ;

BUCKINGHAM, RE ;

CASSIDY, F ;

EVANS, JM ;

FARUK, EA ;

HAMILTON, TC ;

NASH, DJ ;

STEMP, G ;

WILLCOCKS, K .

JOURNAL OF MEDICINAL CHEMISTRY, 1986, 29 (11) :2194-2201

[2] SYNTHESIS OF ANALOGS OF ARACHIDONIC-ACID AS POTENTIAL INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS [J].

BUCKLE, DR ;

FENWICK, AE .

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1989, (03) :477-482

[3] RELAXANT ACTIVITY OF 4-AMIDO-3,4-DIHYDRO-2H-1-BENZOPYRAN-3-OLS AND 4-AMIDO-2H-1-BENZOPYRANS ON GUINEA-PIG ISOLATED TRACHEALIS [J].

BUCKLE, DR ;

ARCH, JRS ;

FENWICK, AE ;

HOUGEFRYDRYCH, CSV ;

PINTO, IL ;

SMITH, DG ;

TAYLOR, SG ;

TEDDER, JM .

JOURNAL OF MEDICINAL CHEMISTRY, 1990, 33 (11) :3028-3034

[4]

EVANS JM, 1991, ANNU REP MED CHEM, V26, P73

[5] INTRAMOLECULAR NUCLEOPHILIC SUBSTITUTIONS OF COORDINATED ARYL HALIDES - A PREPARATION OF CHROMANS [J].

HOUGHTON, RP ;

VOYLE, M ;

PRICE, R .

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1980, (18) :884-885

[6]

WEBSTER RG, COMMUNICATION

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