EFFECT OF NIFEDIPINE ON ALKALOID ACCUMULATION IN CATHARANTHUS-ROSEUS CELL-CULTURES

被引：9
|
作者：
MERILLON, JM [1 ]
LIU, D [1 ]
LAURENT, Y [1 ]
RIDEAU, M [1 ]
VIEL, C [1 ]
机构：
[1] FAC PHARM TOURS,PHARMACOCHIM PROD NAT & ANALOGUES STRUCT LAB,F-37042 TOURS,FRANCE
来源：
PHYTOCHEMISTRY | 1992年 / 31卷 / 05期
关键词：
CATHARANTHUS-ROSEUS; APOCYNACEAE; NIFEDIPINE; NITROPHENYLPYRIDINE; NITROSOPHENYLPYRIDINE; AMINOPHENYLPYRIDINE; CHANNEL BLOCKERS; BIOTRANSFORMATION;
D O I：
10.1016/0031-9422(92)83115-F
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The effect of nifedipine on both alkaloid accumulation and calcium uptake in Catharanthus roseus cell cultures was investigated. It was shown that nifedipine inhibited ajmalicine accumulation through a mechanism other than blocking of the calcium channel uptake. Moreover, nifedipine was biotransformed into its 4-(2'-aminophenyl)-pyridine derivative.
引用
收藏
页码：1609 / 1612
页数：4
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