CRYSTALLOGRAPHY, QUANTITATIVE STRUCTURE ACTIVITY RELATIONSHIPS, AND MOLECULAR GRAPHICS IN A COMPARATIVE-ANALYSIS OF THE INHIBITION OF DIHYDROFOLATE-REDUCTASE FROM CHICKEN LIVER AND LACTOBACILLUS-CASEI BY 4,6-DIAMINO-1,2-DIHYDRO-2,2-DIMETHYL-1-(SUBSTITUTED-PHENYL)-S-TRIAZINESAN

被引:67
作者
HANSCH, C
HATHAWAY, BA
GUO, ZR
SELASSIE, CD
DIETRICH, SW
BLANEY, JM
LANGRIDGE, R
VOLZ, KW
KAUFMAN, BT
机构
[1] UNIV CALIF SAN FRANCISCO,SCH PHARM,DEPT PHARMACEUT CHEM,SAN FRANCISCO,CA 94143
[2] UNIV CALIF SAN DIEGO,DEPT CHEM,LA JOLLA,CA 92093
[3] NIH,BETHESDA,MD 20205
关键词
D O I
10.1021/jm00368a006
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
引用
收藏
页码:129 / 143
页数:15
相关论文
共 46 条
[1]   THE BINDING OF TRIMETHOPRIM TO BACTERIAL DIHYDROFOLATE-REDUCTASE [J].
BAKER, DJ ;
BEDDELL, CR ;
CHAMPNESS, JN ;
GOODFORD, PJ ;
NORRINGTON, FEA ;
SMITH, DR ;
STAMMERS, DK .
FEBS LETTERS, 1981, 126 (01) :49-52
[2]  
Blakley R. L., 1969, FRONT BIOL
[3]  
BOLIN JT, 1982, J BIOL CHEM, V257, P13650
[4]   HYDROBORATION .3. THE REDUCTION OF ORGANIC COMPOUNDS BY DIBORANE, AN ACID-TYPE REDUCING AGENT [J].
BROWN, HC ;
RAO, BCS .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1960, 82 (03) :681-686
[5]   MECHANISM OF ACTION OF TRIMETHOPRIM-SULFAMETHOXAZOLE .2. [J].
BURCHALL, JJ .
JOURNAL OF INFECTIOUS DISEASES, 1973, 128 :S437-S441
[6]   STERIC EFFECTS .1. ESTERIFICATION AND ACID-CATALYZED HYDROLYSIS OF ESTERS [J].
CHARTON, M .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1975, 97 (06) :1552-1556
[7]  
CHARTON M, 1977, DESIGN BIOPHARMACEUT, P228
[8]   COMPARISON OF THE INHIBITION OF METHOTREXATE-SENSITIVE AND METHOTREXATE-RESISTANT LACTOBACILLUS-CASEI CELL-CULTURES WITH PURIFIED LACTOBACILLUS-CASEI DIHYDROFOLATE-REDUCTASE BY 4,6-DIAMINO-1,2-DIHYDRO-2,2-DIMETHYL-1-(3-SUBSTITUTED-PHENYL)-S-TRIAZINES - USE OF QUANTITATIVE STRUCTURE-ACTIVITY-RELATIONSHIPS IN MAKING INFERENCES ABOUT THE MECHANISM OF RESISTANCE AND THE STRUCTURE OF THE ENZYME INSITU COMPARED WITH THE ENZYME INVITROUA [J].
COATS, EA ;
GENTHER, CS ;
DIETRICH, SW ;
GUO, Z ;
HANSCH, C .
JOURNAL OF MEDICINAL CHEMISTRY, 1981, 24 (12) :1422-1429
[9]   QUANTITATIVE STRUCTURE-SELECTIVITY RELATIONSHIPS - COMPARISON OF THE INHIBITION OF ESCHERICHIA-COLI AND BOVINE LIVER DIHYDROFOLATE-REDUCTASE BY 5-(SUBSTITUTED-BENZYL)-2,4-DIAMINOPYRIMIDINES [J].
DIETRICH, SW ;
BLANEY, JM ;
REYNOLDS, MA ;
JOW, PYC ;
HANSCH, C .
JOURNAL OF MEDICINAL CHEMISTRY, 1980, 23 (11) :1205-1212
[10]   USE OF TRIAZINE INHIBITORS IN MAPPING THE ACTIVE-SITE REGION OF LACTOBACILLUS-CASEI DIHYDROFOLATE-REDUCTASE [J].
DIETRICH, SW ;
SMITH, RN ;
BRENDLER, S ;
HANSCH, C .
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1979, 194 (02) :612-619