PENTYLENETETRAZOLE KINDLING IMPAIRS LONG-TERM-MEMORY IN RATS

被引：40

作者：

GENKOVAPAPAZOVA, MG

LAZAROVABAKAROVA, MB

机构：

[1] Department of Experimental Pharmacology, Institute of Physiology, Bulgarian Academy of Sciences, 1113 Sofia

来源：

EUROPEAN NEUROPSYCHOPHARMACOLOGY | 1995年 / 5卷 / 01期

关键词：

PENTYLENETETRAZOLE KINDLING; LEARNING; MEMORY;

D O I：

10.1016/0924-977X(94)00134-W

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The effect of pentylenetetrazole (PTZ) kindling on learning and retention in active (shuttle-box) and passive (step-down) avoidance was studied in rats. PTZ kindling did not impair learning and significantly disturbed long-term memory estimated from retention tests, i.e. PTZ kindling induced a retrograde amnesia in the active and passive avoidance situations. The present results support the view that memory deficit is an integral part of epilepsy.

引用

页码：53 / 56

页数：4

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