DIFFERENT ETIOLOGIES OF TYPE-2 (NON-INSULIN-DEPENDENT) DIABETES-MELLITUS IN OBESE AND NONOBESE SUBJECTS

被引：158

作者：

ARNER, P ^{[1
]}

POLLARE, T ^{[1
]}

LITHELL, H ^{[1
]}

机构：

[1] UNIV UPPSALA,KUNGSGARDETS HOSP,DEPT GERIATR,S-75105 UPPSALA,SWEDEN

来源：

DIABETOLOGIA | 1991年 / 34卷 / 07期

关键词：

INSULIN; GLUCOSE; OBESITY; GLUCOSE DISPOSAL; INSULIN SECRETION;

D O I：

10.1007/BF00403284

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Insulin responses to intravenous glucose infusion and glucose utilization during hyperinsulinaemic euglycaemic clamp were determined in a large homogeneous group of 65-year-old male subjects. Twenty-eight had untreated Type 2 (non-insulin-dependent) diabetes mellitus and the remaining 44 control subjects had a normal glucose tolerance. Diabetic patients with abdominal obesity displayed peripheral insulin resistance in combination with defective insulin secretion, whereas non-obese diabetic patients showed only a secretory defect. Thus, Type 2 diabetes in obese and non-obese elderly male subjects may take two forms where the cause of hyperglycaemia differs.

引用

页码：483 / 487

页数：5

共 24 条

[1] DEFECTIVE INSULIN-RECEPTOR TYROSINE KINASE IN HUMAN SKELETAL-MUSCLE IN OBESITY AND TYPE-2 (NON-INSULIN-DEPENDENT) DIABETES-MELLITUS [J].

ARNER, P ;

POLLARE, T ;

LITHELL, H ;

LIVINGSTON, JN .

DIABETOLOGIA, 1987, 30 (06) :437-440

[2] INSULIN RESISTANCE IN SKELETAL-MUSCLES OF PATIENTS WITH DIABETES-MELLITUS [J].

BECKNIELSEN, H .

DIABETES-METABOLISM REVIEWS, 1989, 5 (06) :487-493

[3] ASSESSMENT OF INSULIN SENSITIVITY INVIVO [J].

BERGMAN, RN ;

FINEGOOD, DT ;

ADER, M .

ENDOCRINE REVIEWS, 1985, 6 (01) :45-86

[4] PERSPECTIVE - DOES INSULIN RESISTANCE PRIMARILY AFFECT SKELETAL-MUSCLE [J].

BOGARDUS, C .

DIABETES-METABOLISM REVIEWS, 1989, 5 (06) :527-528

[5] EFFECTS OF OBESITY, HYPERINSULINEMIA, AND GLUCOSE-INTOLERANCE ON INSULIN ACTION IN ADIPOSE-TISSUE OF 60-YEAR-OLD MEN [J].

BOLINDER, J ;

LITHELL, H ;

SKARFORS, E ;

ARNER, P .

DIABETES, 1986, 35 (03) :282-290

[6] EFFECTS OF INSULIN ON PERIPHERAL AND SPLANCHNIC GLUCOSE-METABOLISM IN NONINSULIN-DEPENDENT (TYPE-II) DIABETES-MELLITUS [J].

DEFRONZO, RA ;

GUNNARSSON, R ;

BJORKMAN, O ;

OLSSON, M ;

WAHREN, J .

JOURNAL OF CLINICAL INVESTIGATION, 1985, 76 (01) :149-155

[7] GLUCOSE-INTOLERANCE AND AGING [J].

DEFRONZO, RA .

DIABETES CARE, 1981, 4 (04) :493-501

[8]

DEFRONZO RA, 1982, DIABETOLOGIA, V23, P313

[9] ASPECTS OF THE PATHOGENESIS OF TYPE-2 DIABETES [J].

EFENDIC, S ;

LUFT, R ;

WAJNGOT, A .

ENDOCRINE REVIEWS, 1984, 5 (03) :395-410

[10] ROLE OF INSULIN RESISTANCE IN THE PATHOGENESIS OF TYPE-2 (NON-INSULIN-DEPENDENT) DIABETES-MELLITUS [J].

GERICH, JE .

BAILLIERES CLINICAL ENDOCRINOLOGY AND METABOLISM, 1988, 2 (02) :307-326

← 1 2 3 →