Proof of concept: liver splitting during normothermic machine perfusion

被引：18

作者：

Stephenson, Barney T. F. ^{[1
,2
]}

Bonney, Glenn K. ^{[3
]}

Laing, Richard W. ^{[1
,2
]}

Bhogal, Ricky H. ^{[1
,2
]}

Marcon, Francesca ^{[1
,2
]}

Neil, Desley A. H. ^{[1
,2
]}

Perera, M. Thamara P. R. ^{[3
]}

Afford, Simon C. ^{[1
,2
]}

Mergental, Hynek ^{[3
]}

Mirza, Darius F. ^{[3
]}

机构：

[1] Univ Birmingham, NIHR Birmingham Liver Biomed Res Unit, Birmingham B15 2TT, W Midlands, England

[2] Univ Birmingham, Liver Res Ctr, Birmingham B15 2TT, W Midlands, England

[3] Univ Hosp Birmingham NHS Fdn Trust, Liver Unit, Queen Elizabeth Hosp, Mindelsohn Way, Birmingham B15 2GW, W Midlands, England

来源：

JOURNAL OF SURGICAL CASE REPORTS | 2018年 / 03期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1093/jscr/rjx218

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Introduction: Despite utilizing extended criteria donors, there remains a shortage of livers for transplantation. No data exists on splitting donor livers with concurrent NMP-L. Methods: A liver recovered from a donor after circulatory death was subjected to NMP-L using a red cell based fluid. During NMP-L, a 'classical' left lateral + right trisegmentectomy split was performed using an integrated bipolar/ultrasonic device. After splitting, blood flow was confirmed using Doppler ultrasound in each lobe. Results: Prior to splitting, flow rates were maintained physiologically. Lactate decreased from 13.9 to 3.0 mmol/L. Lactate before and after splitting were similar in the hepatic arteries, portal veins and IVC. Doppler ultrasound demonstrated arterial and venous waveforms in both lobes after splitting. Conclusions: 'Classical' liver splitting during NMP-L is feasible, maintaining viability of both lobes. Establishing this procedure may attenuate cold ischaemic injury, allow pre-implantation monitoring of both grafts and facilitate logistics of transplanting two grafts.

引用

页数：6

共 4 条

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