MOLECULAR-CLONING AND CHROMOSOMAL LOCALIZATION OF THE HUMAN ALPHA(7)-NICOTINIC RECEPTOR SUBUNIT GENE (CHRNA7)

被引：87
作者：
CHINI, B
RAIMOND, E
ELGOYHEN, AB
MORALLI, D
BALZARETTI, M
HEINEMANN, S
机构：
[1] SALK INST BIOL STUDIES,MOLEC NEUROBIOL LAB,LA JOLLA,CA 92037
[2] DIPARTIMENTO GENET & MICROBIOL A BUZZATI TRAVERSO,I-27100 PAVIA,ITALY
来源：
GENOMICS | 1994年 / 19卷 / 02期
关键词：
D O I：
10.1006/geno.1994.1075
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
We have isolated cDNA and genomic clones coding for the human alpha(7) neuronal nicotinic receptor subunit, the major component of brain nicotinic receptors that are blocked by alpha-bungarotoxin. The human alpha(7) neuronal nicotinic cDNA encodes a mature protein of 479 amino acids that is highly homologous to the rat alpha(7) neuronal nicotinic subunit (90%). We have mapped the human alpha(7)-nicotinic receptor subunit gene to chromosome 15, band q14, a region frequently rearranged in patients carrying a bisatellite 15 chromosome, large inv dup (15), whose clinical features include mental retardation and seizures. (C) 1994 Academic Press, Inc.
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页码：379 / 381
页数：3
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