HYPERVARIABLE REGIONS IN THE PUTATIVE GLYCOPROTEIN OF HEPATITIS-C VIRUS

被引：310

作者：

HIJIKATA, M

KATO, N

OOTSUYAMA, Y

NAKAGAWA, M

OHKOSHI, S

SHIMOTOHNO, K

机构：

[1] Virology Division, National Cancer Center Research Institute, Chuo-ku, Tokyo, 104, 5-1-1, Tsukiji

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1991年 / 175卷 / 01期

关键词：

D O I：

10.1016/S0006-291X(05)81223-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A comparison of the sequences of the putative glycoprotein region in three independent cDNA clones of hepatitis C virus and of sequences of four other clones revealed extensive genetic variation clustered and interspersed with highly conserved amino acid sequences. We obtained evidence for two hypervariable regions in the putative envelope glycoprotein, one region was assumed to be a potential antigenic site, as deduced from the hydrophilicity and analyses of secondary structures. These observations suggest the existence of a large pool of antigenic variants of hepatitis C virus, in Japan. © 1991 Academic Press, Inc.

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页码：220 / 228

页数：9

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