CYTOKINES - IS THERE BIOLOGICAL MEANING

被引：25

作者：

MOSMANN, TR

机构：

[1] University of Alberta, Edmonton, Alta.

来源：

CURRENT OPINION IN IMMUNOLOGY | 1991年 / 3卷 / 03期

关键词：

D O I：

10.1016/0952-7915(91)90029-Z

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In the immune system, amidst the bewildering array of cytokine functions, it is sometimes difficult to discern the relative physiological importance of functions that have been determined in tissue culture. Cytokine functions are indeed complex, but the analysis of relatively simple regulatory networks suggests that activities determined in vitro are highly relevant to genuine physiological functions.

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页码：311 / 314

页数：4

相关论文

共 23 条

[1]

BELOSEVIC M, 1989, J IMMUNOL, V143, P266

[2] FURTHER-STUDIES ON THYMOCYTE STIMULATING FACTOR [J].

CHEN, DM ;

DISABATO, G .

CELLULAR IMMUNOLOGY, 1976, 22 (02) :211-224

[3]

CHER DJ, 1987, J IMMUNOL, V138, P3688

[4] 2 TYPES OF MOUSE HELPER T-CELL CLONE .3. FURTHER DIFFERENCES IN LYMPHOKINE SYNTHESIS BETWEEN TH1 AND TH2 CLONES REVEALED BY RNA HYBRIDIZATION, FUNCTIONALLY MONOSPECIFIC BIOASSAYS, AND MONOCLONAL-ANTIBODIES [J].

CHERWINSKI, HM ;

SCHUMACHER, JH ;

BROWN, KD ;

MOSMANN, TR .

JOURNAL OF EXPERIMENTAL MEDICINE, 1987, 166 (05) :1229-1244

[5]

COFFMAN RL, 1986, J IMMUNOL, V136, P4538

[6] THE ROLE OF HELPER T-CELL PRODUCTS IN MOUSE B-CELL DIFFERENTIATION AND ISOTYPE REGULATION [J].

COFFMAN, RL ;

SEYMOUR, BWP ;

LEBMAN, DA ;

HIRAKI, DD ;

CHRISTIANSEN, JA ;

SHRADER, B ;

CHERWINSKI, HM ;

SAVELKOUL, HFJ ;

FINKELMAN, FD ;

BOND, MW ;

MOSMANN, TR .

IMMUNOLOGICAL REVIEWS, 1988, 102 :5-28

[7] ANTIBODY TO INTERLEUKIN-5 INHIBITS HELMINTH-INDUCED EOSINOPHILIA IN MICE [J].

COFFMAN, RL ;

SEYMOUR, BWP ;

HUDAK, S ;

JACKSON, J ;

RENNICK, D .

SCIENCE, 1989, 245 (4915) :308-310

[8] EOSINOPHILIA IN TRANSGENIC MICE EXPRESSING INTERLEUKIN-5 [J].

DENT, LA ;

STRATH, M ;

MELLOR, AL ;

SANDERSON, CJ .

JOURNAL OF EXPERIMENTAL MEDICINE, 1990, 172 (05) :1425-1431

[9] LYMPHOKINE-MEDIATED REGULATION OF THE PROLIFERATIVE RESPONSE OF CLONES OF T-HELPER-1 AND T-HELPER-2 CELLS [J].

FERNANDEZBOTRAN, R ;

SANDERS, VM ;

MOSMANN, TR ;

VITETTA, ES .

JOURNAL OF EXPERIMENTAL MEDICINE, 1988, 168 (02) :543-558

[10] LYMPHOKINE CONTROL OF INVIVO IMMUNOGLOBULIN ISOTYPE SELECTION [J].

FINKELMAN, FD ;

HOLMES, J ;

KATONA, IM ;

URBAN, JF ;

BECKMANN, MP ;

PARK, LS ;

SCHOOLEY, KA ;

COFFMAN, RL ;

MOSMANN, TR ;

PAUL, WE .

ANNUAL REVIEW OF IMMUNOLOGY, 1990, 8 :303-333