MOLECULAR-CLONING AND CHARACTERIZATION OF A NOVEL DOPAMINE RECEPTOR (D3) AS A TARGET FOR NEUROLEPTICS

被引：2541

作者：

SOKOLOFF, P ^{[1
]}

GIROS, B ^{[1
]}

MARTRES, MP ^{[1
]}

BOUTHENET, ML ^{[1
]}

SCHWARTZ, JC ^{[1
]}

机构：

[1] UNIV PARIS 05, FAC PHARM, PHYSIOL LAB, F-75270 PARIS 06, FRANCE

来源：

NATURE | 1990年 / 347卷 / 6289期

关键词：

D O I：

10.1038/347146a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A dopamine receptor has been characterized which differs in its pharmacology and signalling system from the D1 or D2 receptor and represents both an autoreceptor and a postsynaptic receptor. The D3 receptor is localized to limbic areas of the brain, which are associated with cognitive, emotional and endocrine functions. It seems to mediate some of the effects of antipsychotic drugs and drugs used against Parkinson's disease, that were previously thought to interact only with D2 receptors. © 1990 Nature Publishing Group.

引用

页码：146 / 151

页数：6

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