RELB, A NEW REL FAMILY TRANSCRIPTION ACTIVATOR THAT CAN INTERACT WITH P50-NF-KAPPA-B

被引:357
作者
RYSECK, RP
BULL, P
TAKAMIYA, M
BOURS, V
SIEBENLIST, U
DOBRZANSKI, P
BRAVO, R
机构
[1] BRISTOL MYERS SQUIBB,PHARMACEUT RES INST,DEPT MOLEC BIOL,POB 4000,PRINCETON,NJ 08543
[2] CATHOLIC UNIV CHILE,DEPT BIOL CELULAR & MOLEC,SANTIAGO,CHILE
[3] NIAID,IMMUNOREGULAT LAB,BETHESDA,MD 20892
关键词
D O I
10.1128/MCB.12.2.674
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
We have identified a serum-inducible gene, relB, which encodes a protein of 558 amino acids containing a region with high similarity to c-Rel and other members of the Rel family. Transcriptional activation analysis of GAL4-RelB fusion proteins in yeast cells reveals that RelB contains in its C-terminal 180 amino acids a transcriptional activation domain. The N-terminal part including the region of similarity with the Rel family shows no detectable transcriptional activity. RelB does not bind with high affinity to NF-kappa-B sites, but heterodimers between RelB and p50-NF-kappa-B do bind to different NF-kappa-B-binding sites with a similar affinity to that shown by p50-NF-kappa-B homodimers. However, RelB/p50-NF-kappa-B heterodimers, in contrast to p50-NF-kappa-B homodimers, transactivate transcription of a promoter containing a kappa-B-binding site.
引用
收藏
页码:674 / 684
页数:11
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