LITHIUM TREATMENT RESTORES CLONIDINES EFFECT IN AN ANIMAL-MODEL OF DEPRESSION

被引：4
|
作者：
AULAKH, CS
HILL, JL
MURPHY, DL
机构：
[1] Laboratory of Clinical Science, National Institute of Mental Health, Bethesda
来源：
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR | 1994年 / 47卷 / 04期
关键词：
ALPHA(2)-ADRENERGIC HETERORECEPTORS; 5-HT1C RECEPTORS; DEPRESSION; GROWTH HORMONE; FAWN-HOODED RAT;
D O I：
10.1016/0091-3057(94)90308-5
中图分类号：
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号：
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要：
IP administration of various doses of clonidine produces significant increases in growth hormone levels in the Wistar rats but not in the Fawn-Hooded (FH) rats, a rat strain suggested to be a genetic model of depression. However, short-term lithium treatment restores clonidine's effect on growth hormone levels in the Fawn-Hooded rats. Potentiation of clonidine's effect on growth hormone levels following short-term lithium treatment appears most likely due to increased serotonergic function as a consequence of enhanced 5-HT concentrations at postsynaptic 5-HT1C receptor sites. Thus, the reversal of a deficit state in Fawn-Hooded rats by lithium treatment supports earlier studies suggesting this rat strain to represent a genetic model of depression.
引用
收藏
页码：985 / 987
页数：3
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