STUDY OF THE CATALYTIC POLAROGRAPHIC PREWAVE OF NICKEL(II) INDUCED BY CIMETIDINE

被引：4
作者：
FONSECA, JML
FOJON, D
机构：
[1] Department of Physical Chemistry, Faculty of Pharmacy, University of Santiago
来源：
ANALYTICAL LETTERS | 1992年 / 25卷 / 06期
关键词：
POLAROGRAPHY; NI(II) CATALYTIC PREWAVE; CIMETIDINE DETERMINATION;
D O I：
10.1080/00032719208020062
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
We carried out a comprehensive study of the Ni(II) pre-wave induced by cimetidine in sodium veronal - nitric acid - sodium nitrate media using various polarographic techniques in order to establish the mechanism of the electrode process. This was found to involve the formation of catalytic complexes of the aquo-Ni(II) and veronal-Ni(II) ions with deprotonated cimetidine adsorbed on the electrode surface, which was followed by reduction of the Ni(II) in the complexes and the consequent release of the catalytic ligand. The pre-peak obtained by differential pulse polarography for the 5.10(-4)M Ni(II) - 5.10(-3)M sodium veronal -HNO3-NaNO3 system (pH 8.5, ionic strength 0.4 M) can be exploited for the quantitative determination of cimetidine over the concentration range 1.10(-6) -1.10(-5) M.
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页码：1095 / 1109
页数：15
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