CARBOHYDRATE-CARBOHYDRATE INTERACTION AS AN INITIAL STEP IN CELL RECOGNITION

被引：176

作者：

HAKOMORI, S ^{[1
]}

机构：

[1] UNIV WASHINGTON,SEATTLE,WA 98195

来源：

PURE AND APPLIED CHEMISTRY | 1991年 / 63卷 / 04期

关键词：

D O I：

10.1351/pac199163040473

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Specific interaction between specific carbohydrate moieties of glycosphingolipids (GSLs) has been demonstrated based on interaction of GSL-containing liposomes with GSL-coated solid phase, and affinity adsorption of multivalent GSL oligosaccharide on solid-phase GSL column. Evidence is presented that such GSL-GSL interaction is an initial step in the cell recognition process. Examples are Le(x)-Le(x) interaction at the morula stage of mouse embryogenesis, Gg3-GM3 interaction in melanoma/lymphoma cell interaction, and galactosylceramide-sulfatide interaction in myelin sheath membrane formation. The molecular basis of such interactions is discussed.

引用

页码：473 / 482

页数：10

共 31 条

[11] INTEGRINS - A FAMILY OF CELL-SURFACE RECEPTORS [J].