CARBOHYDRATE-CARBOHYDRATE INTERACTION AS AN INITIAL STEP IN CELL RECOGNITION

被引：176
作者：
HAKOMORI, S [1 ]
机构：
[1] UNIV WASHINGTON,SEATTLE,WA 98195
来源：
PURE AND APPLIED CHEMISTRY | 1991年 / 63卷 / 04期
关键词：
D O I：
10.1351/pac199163040473
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Specific interaction between specific carbohydrate moieties of glycosphingolipids (GSLs) has been demonstrated based on interaction of GSL-containing liposomes with GSL-coated solid phase, and affinity adsorption of multivalent GSL oligosaccharide on solid-phase GSL column. Evidence is presented that such GSL-GSL interaction is an initial step in the cell recognition process. Examples are Le(x)-Le(x) interaction at the morula stage of mouse embryogenesis, Gg3-GM3 interaction in melanoma/lymphoma cell interaction, and galactosylceramide-sulfatide interaction in myelin sheath membrane formation. The molecular basis of such interactions is discussed.
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页码：473 / 482
页数：10
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