EFFECTS OF CHARGE, VOLUME, AND SURFACE ON BINDING OF INHIBITOR AND SUBSTRATE MOIETIES TO ACETYLCHOLINESTERASE

被引：20

作者：

COHEN, SG ^{[1
]}

CHISHTI, SB ^{[1
]}

ELKIND, JL ^{[1
]}

REESE, H ^{[1
]}

COHEN, JB ^{[1
]}

机构：

[1] WASHINGTON UNIV,SCH MED,DEPT ANAT & NEUROBIOL,ST LOUIS,MO 63110

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1985年 / 28卷 / 09期

关键词：

D O I：

10.1021/jm00147a033

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

引用

页码：1309 / 1313

页数：5

共 23 条

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[4] EFFECTS OF VOLUME AND SURFACE-PROPERTY IN HYDROLYSIS BY ACETYLCHOLINESTERASE - THE TRIMETHYL SITE [J].

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ELKIND, JL ;

CHISHTI, SB ;

GINER, JLP ;

REESE, H ;

COHEN, JB .

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[5]

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[6] ALIPHATIC-KETONES ARE ACETYLCHOLINESTERASE INHIBITORS BUT NOT TRANSITION-STATE ANALOGS [J].

DAFFORN, A ;

JEWELL, M ;

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ASH, D ;

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RYCH, G .

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[7]

DAWSON RM, 1978, J NEUROCHEM, V30, P865

[8]

Hansch C, 1979, SUBSTITUENT CONSTANT

[9]

HASAN FB, 1981, J BIOL CHEM, V256, P7781

[10]

HASAN FB, 1980, J BIOL CHEM, V255, P3898

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