Incidence of Anaphylaxis Associated With Sugammadex

被引：73

作者：

Miyazaki, Yusuke ^{[1
]}

Sunaga, Hiroshi ^{[1
]}

Kida, Kotaro ^{[1
]}

Hobo, Shotaro ^{[2
]}

Inoue, Nobuyoshi ^{[1
]}

Muto, Masayuki ^{[1
]}

Uezono, Shoichi ^{[1
]}

机构：

[1] Jikei Univ, Sch Med, Dept Anesthesiol, Tokyo, Japan

[2] Mitsui Mem Hosp, Dept Anesthesiol, Tokyo, Japan

来源：

ANESTHESIA AND ANALGESIA | 2018年 / 126卷 / 05期

关键词：

ROCURONIUM;

D O I：

10.1213/ANE.0000000000002562

中图分类号：

R614 [麻醉学];

学科分类号：

100217 ;

摘要：

We retrospectively investigated the incidence of potential sugammadex-induced anaphylaxis at a single center in Japan over a period of 3 years. The overall incidence of intraoperative hypersensitivity reaction was 0.22% (95% confidence interval [CI], 0.17%-0.29%), and the incidence of anaphylaxis was 0.059% (95% CI, 0.032%-0.10%). The total number of patients who received sugammadex during the study period was 15,479, and the incidence of anaphylaxis associated with sugammadex was 0.039% (n = 6; 95% CI, 0.014%-0.084%). This result implies that the incidence of sugammadex-associated anaphylaxis could be as high as that for succinylcholine or rocuronium. A prospective study, including testing for identification of cause, is necessary to confirm the exact incidence of sugammadex-induced anaphylaxis; however, the present finding calls attention to this potential.

引用

页码：1505 / 1508

页数：4

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