ISOLATED ADRENOCORTICOTROPIC HORMONE DEFICIENCY SECONDARY TO HYPOTHALAMIC DEFICIT OF CORTICOTROPIN RELEASING HORMONE

被引：10

作者：

VELARDO, A ^{[1
]}

PANTALEONI, M ^{[1
]}

ZIZZO, G ^{[1
]}

DELRIO, G ^{[1
]}

COLETTA, F ^{[1
]}

CARANI, C ^{[1
]}

MARRAMA, P ^{[1
]}

机构：

[1] UNIV MODENA,CATTEDRA MALATTIE METAB,I-41100 MODENA,ITALY

来源：

JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION | 1992年 / 15卷 / 01期

关键词：

D O I：

10.1007/BF03348660

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A 42-year-old man and a 51-year-old woman with a positive history of weakness and gastrointestinal complaints were shown to have low basal plasma cortisol and ACTH levels, and low daily urinary excretion of free cortisol. An empty sella was found in patient no. 1, while patient no. 2 was hypothyroid. Both patients showed a normal plasma cortisol response to ACTH and an increment in plasma ACTH and lipotropin levels after ovine CRH (oCRH), lysine vasopressin (LVP) and oCRH-LVP stimulation tests. These studies clearly report an isolated idiopathic ACTH deficiency due to a deficit in CRH in two adult subjects.

引用

页码：53 / 57

页数：5

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