GENERATION OF T MEMORY CELLS IN ONE-WAY MIXED LYMPHOCYTE CULTURE .4. PRIMARY AND SECONDARY RESPONSES TO SOLUBLE AND INSOLUBLE MEMBRANE PREPARATIONS AND TO ULTRAVIOLET-LIGHT INACTIVATED STIMULATOR CELLS

被引：65
作者：
HAYRY, P
ANDERSSON, LC
机构：
[1] UNIV CENT HOSP HELSINKI, DEPT SURG 4, SF-00290 HELSINKI 29, FINLAND
[2] UNIV HELSINKI, DEPT PATHOL 3, SF-00290 HELSINKI, FINLAND
来源：
SCANDINAVIAN JOURNAL OF IMMUNOLOGY | 1976年 / 5卷 / 04期
关键词：
D O I：
10.1111/j.1365-3083.1976.tb00293.x
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Neither normal CBA (H-2k) nor purified spleen T [thymus-derived] cells respond in vitro to soluble or insoluble membrane preparations or to UV-light-inactivated stimulator cells of the allogeneic DBA/2 (H-2d) strain. CBA spleen cells deprived of phagocytic cells show a slight proliferative response under these conditions. After being primed against mitomycin-blocked DBA/2 cells in 1-way mixed lymphocyte culture, the secondary blast-derived T memory cells display a good secondary blast (proliferative) response to membrane antigens and to UV-light-inactivated stimulator cells. The secondary T lymphocytes, in contrast to nonprimed T cells, respond by cytotoxicity when UV-light-inactivated cells are used as the 2nd stimulant.
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页码：391 / 399
页数：9
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