REPAIR OF UV-INDUCED PYRIMIDINE(6-4)PYRIMIDONE PHOTOPRODUCTS IS SELECTIVELY INHIBITED IN TRANSCRIPTIONALLY ACTIVE GENES AFTER HEAT-TREATMENT OF HUMAN FIBROBLASTS

被引：9
|
作者：
SAKKERS, RJ
FILON, AR
KAMPINGA, HH
KONINGS, AWT
MULLENDERS, LHF
机构：
[1] JA COHEN INST,INTERUNIV RES INST RADIOPATHOL & RADIAT PROTECT,LEIDEN,NETHERLANDS
[2] UNIV GRONINGEN,DEPT RADIOBIOL,9713 BZ GRONINGEN,NETHERLANDS
来源：
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY | 1995年 / 67卷 / 05期
关键词：
D O I：
10.1080/09553009514550601
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
In normal human fibroblasts, repair of(6-4)PP in the active adenosine deaminase (ADA) gene occurs with similar rate in the transcribed and non-transcribed strand of the ADA gene, and removal of (6-4)PP from the active ADA gene is faster than from the inactive X-chromosomal 754 locus. Heat shock decreased the rate of repair of the active ADA gene down to the level of inactive genes, whereas the rate of repair of the inactive 754 locus was not affected.
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页码：495 / 499
页数：5
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