A LOW-THRESHOLD SUSTAINED INWARD CURRENT ACTIVATED AT THE DIASTOLIC POTENTIAL RANGE IN RABBIT SINOATRIAL NODE CELLS

被引：0

作者：

GUO, JQ ^{[1
]}

ONO, K ^{[1
]}

NOMA, A ^{[1
]}

机构：

[1] NANJING COLL TRAD CHINESE MED,DEPT PHYSIOL,NANJING 210029,PEOPLES R CHINA

来源：

HEART AND VESSELS | 1995年

关键词：

PACEMAKER CURRENT; SINOATRIAL NODE; DIASTOLIC DEPOLARIZATION; CA2+ CHANNEL;

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The whole-cell voltage clamp was performed in myocytes dissociated from the rabbit sinoatrial node using the collagenase method. After blocking both the hyperpolarization-activated current and the membrane K+ conductance, depolarizations from -80 mV to values in the range -70 to -50 mV induced a sustained current. This low-threshold sustained inward current was blocked by both organic and inorganic Ca2+ channel blockers, but tetrodotoxin 30 mu M was ineffective. Isoprenaline increased this current. It is suggested that this current plays an important role in driving the diastolic depolarization.

引用

页码：200 / 202

页数：3