ACUTE ETHANOL INGESTION MODIFIES THE CIRCULATING PLASMA-LEVELS OF ATRIAL-NATRIURETIC-PEPTIDE

被引:14
作者
WIGLE, DA
PANG, SC
SARDA, IR
WATSON, JD
RADAKOVIC, NN
ROY, R
FLYNN, TG
机构
[1] QUEENS UNIV,DEPT ANAT,KINGSTON K7L 3N6,ONTARIO,CANADA
[2] QUEENS UNIV,DEPT BIOCHEM,KINGSTON K7L 3N6,ONTARIO,CANADA
基金
英国医学研究理事会;
关键词
ALCOHOL; ANP; VASOPRESSIN; ALDOSTERONE; RENIN;
D O I
10.1016/0741-8329(93)90005-9
中图分类号
R194 [卫生标准、卫生检查、医药管理];
学科分类号
摘要
Since ethanol ingestion is associated with a disruption of water and electrolyte balance in a variety of species, we sought to evaluate the regulatory control of atrial natriuretic peptide (ANP) in response to acute doses of ethanol. Male Sprague-Dawley rats were administered a 5-g/kg dose of ethanol (40% w/v) via a gastric tube, while control animals received an equivalent volume of water. Expressed as a percentage of control, plasma ANP levels were 39.0%, 28.5%, and 23.6% in the ethanol-treated animals at 30, 60, and 120 min postintubation, respectively. Ethanol-treated animals displayed blood alcohol concentrations of 89.0, 137.6, and 214.1 mg/dl at the same time periods. After 120 min, plasma renin activity was elevated from 8.7 to 20.3 ng/ml/h in conjunction with an increase in the levels of circulating aldosterone from 16.3 to 42.5 ng/dl and an increase in plasma vasopressin from 2.2 to 3.6 pg/ml. Levels of atrial ANP mRNA remained consistent over the time course of the experiment, and no changes in the amount of ventricular ANP transcript were observed. Tissue ANP levels were similar between ethanol-treated and water-loaded control animals. In vitro experiments using cultured cardiac myocytes suggest that ethanol exposure may not directly affect ANP secretion. We propose that acute ethanol treatment may inhibit atrial distension and subsequently modify the control of ANP release under volume loading conditions.
引用
收藏
页码:275 / 280
页数:6
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