TREATMENT OF LEPTOMENINGEAL CARCINOMATOSIS WITH CONTINUOUS INTRAVENTRICULAR INFUSION OF RECOMBINANT INTERLEUKIN-2

被引：17
作者：
HEIMANS, JJ
WAGSTAFF, J
SCHREUDER, WO
WOLBERS, JG
BAARS, JW
POLMAN, CH
SCHARENBERG, JG
SCHEPER, RJ
PALMER, PA
FRANKS, CR
机构：
[1] FREE UNIV AMSTERDAM HOSP, DEPT NEUROSURG, 1007 MB AMSTERDAM, NETHERLANDS
[2] FREE UNIV AMSTERDAM HOSP, DEPT MED ONCOL, 1007 MB AMSTERDAM, NETHERLANDS
[3] FREE UNIV AMSTERDAM HOSP, DEPT IMMUNOL, 1007 MB AMSTERDAM, NETHERLANDS
[4] EUROCETUS, AMSTERDAM, NETHERLANDS
来源：
SURGICAL NEUROLOGY | 1991年 / 35卷 / 03期
关键词：
LEPTOMENINGEAL CARCINOMATOSIS; MELANOMA; INTERLEUKIN-2; INTRAVENTRICULAR TREATMENT;
D O I：
10.1016/0090-3019(91)90079-O
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
A 42-year-old man developed leptomeningeal carcinomatosis 6 years after treatment of a malignant melanoma. He was treated with two courses of recombinant interleukin-2, administered as a continuous intraventricular infusion (6 x 10E5 U/24 h) during 5 days. During the first day of the first course he also received 5 x 10E9 lymphokine-activated killer cells intraventricularly. This gave rise to a severe elevation of intracranial pressure, with headaches and meningismus. During the second course no LAK cells were administered. This course was tolerated much better. The neurological status did not change during the treatment. Recombinant interleukin-2 levels were maintained at about 300 U/mL during both courses.
引用
收藏
页码：244 / 247
页数：4
相关论文
共 16 条
[11]  
WASSERSTROM WR, 1982, CANCER, V49, P759, DOI 10.1002/1097-0142(19820215)49:4<759::AID-CNCR2820490427>3.0.CO
[12]  
2-7
[13]   THE HTLV-III ENVELOPE PROTEIN CONTAINS A HEXAPEPTIDE HOMOLOGOUS TO A REGION OF INTERLEUKIN-2 THAT BINDS TO THE INTERLEUKIN-2 RECEPTOR [J].
WEIGENT, DA ;
HOEPRICH, PD ;
BOST, KL ;
BRUNCK, TK ;
REIHER, WE ;
BLALOCK, JE .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1986, 139 (01) :367-374
[14]  
YAP HY, 1982, CANCER-AM CANCER SOC, V50, P219, DOI 10.1002/1097-0142(19820715)50:2<219::AID-CNCR2820500209>3.0.CO
[15]  
2-7
[16]  
YOUNG DF, 1975, NEUROLOGY, V25, P370
12