SYNTHESIS AND EVALUATION OF MONOFLUOROETHENYL-GABA, DIFLUOROETHENYL-GABA, AND TRIFLUOROETHENYL-GABA DERIVATIVES AS GABA-T INHIBITORS

被引：58
作者：
KOLB, M
BARTH, J
HEYDT, JG
JUNG, MJ
机构：
来源：
JOURNAL OF MEDICINAL CHEMISTRY | 1987年 / 30卷 / 02期
关键词：
D O I：
10.1021/jm00385a007
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
引用
收藏
页码：267 / 272
页数：6
相关论文
共 35 条
[1]   INACTIVATION OF GAMMA-CYSTATHIONASE BY GAMMA-FLUORINATED AMINO-ACIDS [J].
ALSTON, TA ;
MURAMATSU, H ;
UEDA, T ;
BRIGHT, HJ .
FEBS LETTERS, 1981, 128 (02) :293-297
[2]   SYNTHESES OF ORGANOFLUORINE COMPOUNDS .8. SOLVOLYTIC RING-OPENING OF ALKOXYCHLOROFLUOROCYCLOPROPANES - READY ACCESS TO FLUORINATED ALPHA-BETA-UNSATURATED ALDEHYDES AND KETONES [J].
BESSIERE, Y ;
SAVARY, DNH ;
SCHLOSSER, M .
HELVETICA CHIMICA ACTA, 1977, 60 (05) :1739-1746
[3]   STEREOSPECIFIC PREPARATION OF (Z)-ISOMERS AND (E)-ISOMERS, RESPECTIVELY, OF SOME VINYL FLUORIDES [J].
BOCHE, G ;
FAHRMANN, U .
CHEMISCHE BERICHTE-RECUEIL, 1981, 114 (12) :4005-4009
[4]  
BOWERS A, 1968, J AM CHEM SOC, V90, P947
[5]   PREPARATION AND REACTIONS OF SOME FLUORINE-CONTAINING VINYL ORGANOMETALLIC COMPOUNDS [J].
DRAKESMITH, FG ;
RICHARDS.RD ;
STEWART, OJ ;
TARRANT, P .
JOURNAL OF ORGANIC CHEMISTRY, 1968, 33 (01) :286-+
[6]  
FORCHE E, 1962, METHODEN ORGANISCHEN, V5, P247
[7]  
GITTOS M, 1979, Patent No. 873766
[8]  
HERRMANN JL, 1973, TETRAHEDRON LETT, P4711
[9]   KINETIC AND SPECTRAL PROPERTIES OF RABBIT BRAIN 4-AMINOBUTYRATE AMINOTRANSFERASE [J].
JOHN, RA ;
FOWLER, LJ .
BIOCHEMICAL JOURNAL, 1976, 155 (03) :645-651
[10]   GAMMA-VINYL GABA (4-AMINO-HEX-5-ENOIC ACID), A NEW SELECTIVE IRREVERSIBLE INHIBITOR OF GABA-T - EFFECTS ON BRAIN GABA METABOLISM IN MICE [J].
JUNG, MJ ;
LIPPERT, B ;
METCALF, BW ;
BOHLEN, P ;
SCHECHTER, PJ .
JOURNAL OF NEUROCHEMISTRY, 1977, 29 (05) :797-802
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