Probiotic Lactobacillus rhamnosus GR-1 and Lactobacillus reuteri RC-14May Help Downregulate TNF-Alpha, IL-6, IL-8, IL-10 and IL-12 ( p70) in the Neurogenic Bladder of Spinal Cord Injured Patient with Urinary Tract Infections: A Two-Case Study

被引：27

作者：

Anukam, Kingsley C. ^{[1
,2
]}

Hayes, Keith ^{[3
]}

Summers, Kelly ^{[2
]}

Reid, Gregor ^{[1
,2
]}

机构：

[1] Canadian Res & Dev Ctr Probiot, Lawson Hlth Res Inst, London, ON N6A 4V2, Canada

[2] Univ Western Ontario, Dept Microbiol & Immunol, London, ON N6A 3K7, Canada

[3] Univ Western Ontario, Dept Phys Med & Rehabil, London, ON N6A 3K7, Canada

来源：

ADVANCES IN UROLOGY | 2009年 / 2009卷

关键词：

D O I：

10.1155/2009/680363

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

The management of urinary tract infection (UTI) in individuals with spinal cord injury (SCI) continues to be of concern, due to complications that can occur. An emerging concept that is a common underlying pathophysiological process is involved, wherein pathogens causing UTI have a role in inflammatory progression. We hypothesized that members of the commensal flora, such as lactobacilli, may counter this reaction through anti-inflammatory mediation. This was assessed in a pilot two-patient study in which probiotic Lactobacillus rhamnosus GR-1 and Lactobacillus reuteri were administered to one patient and placebo to another, both along with antibiotics to treat acute UTI. Urinary TNF-alpha was significantly downregulated (P =.015) in the patient who received the probiotic and who used intermittent catheterization compared with patient on placebo and using an indwelling catheter. The extent to which this alteration resulted in improved well-being in spinal cord injured patients remains to be determined in a larger study. Copyright (C) 2009 Kingsley C. Anukam et al.

引用

页数：5