RECOVERY IN HEMIPARKINSONIAN RATS FOLLOWING INTRASTRIATAL IMPLANTATION OF ACTIVATED LEUKOCYTES

被引：30
作者：
EWING, SE
WEBER, RJ
ZAUNER, A
PLUNKETT, RJ
机构：
[1] NINCDS, SURG NEUROL BRANCH, BETHESDA, MD 20892 USA
[2] NIDDKD, MED CHEM LAB, NEUROIMMUNOL UNIT, BETHESDA, MD 20892 USA
来源：
BRAIN RESEARCH | 1992年 / 576卷 / 01期
基金：
美国国家卫生研究院;
关键词：
6-HYDROXYDOPAMINE; HEMIPARKINSONIAN RAT; ACTIVATED LEUKOCYTE; CENTRAL NERVOUS SYSTEM IMPLANTATION; FLUORESCENT ACTIVATED CELL SORTING;
D O I：
10.1016/0006-8993(92)90607-B
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Behavioral improvement has been seen in hemiparkinsonian animals after surgical lesions of the denervated caudate nucleus. This study was designed to investigate the role of inflammatory cells in injury-induced recovery. A hemiparkinsonian syndrome was induced in rats by unilateral injections of 6-hydroxydopamine into the pars compacta of the substantia nigra. Phytohemagglutinin-stimulated rat peritoneal cells, predominantly T cells and macrophages, were stereotactically implanted in the lesioned caudate-putamen, and amphetamine-induced turning was used to assess recovery. Animals receiving implants of activated peritoneal cells showed a 47% decrease in amphetamine-induced turning 8 weeks after implantation, which was not seen in control or sham-operated animals. Immunocytochemistry revealed increased tyrosine hydroxylase reactive fibers in the leukocyte-implanted striatum. We conclude that implantation of activated leukocytes promotes functional recovery in hemiparkinsonian rats.
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页码：42 / 48
页数：7
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