DEPLETION OF SIALIC-ACID WITHOUT CHANGES IN SIALIDASE ACTIVITY IN GLOMERULI OF UNINEPHRECTOMIZED DIABETIC RATS

被引：11
作者：
CARDENAS, A
SCHADECK, C
BERNARD, A
LAUWERYS, R
机构：
[1] Unit of Industrial Toxicology, Occupational Medicine Catholic University of Louvain Clos Chapelle-aux Champs
来源：
BIOCHEMICAL MEDICINE AND METABOLIC BIOLOGY | 1991年 / 46卷 / 03期
关键词：
D O I：
10.1016/0885-4505(91)90089-4
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The role of sialidase in the depletion of glomerular sialic acid induced by diabetes has been investigated in uninephrectomized rats. Four months after streptozotocin administration, diabetic rats showed an enhanced urinary excretion of albumin and transferrin, which was associated with a decrease of sialic acid concentration in isolated glomeruli. Despite the sialic acid depletion, the glomerular sialidase activity was unchanged. These results indicate that the decreased glomerular sialic acid concentration observed in diabetic nephropathy might be caused by a disturbance of the sialylation of glomerular structures. © 1991.
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页码：416 / 421
页数：6
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