SUPPRESSION OF ADRENOCORTICOTROPIC HORMONE (ACTH)-INDUCED CORTICOSTERONE SECRETION IN CULTURED RAT ADRENOCORTICAL-CELLS BY GOSSYPOL AND GOSSYPOLONE

被引:0
作者
GU, Y [1 ]
LIN, YC [1 ]
机构
[1] OHIO STATE UNIV,COLL VET MED,DEPT VET PHYSIOL & PHARMACOL,REPROD ENDOCRINOL LAB,1900 COFFEY RD,COLUMBUS,OH 43210
来源
RESEARCH COMMUNICATIONS IN CHEMICAL PATHOLOGY AND PHARMACOLOGY | 1991年 / 72卷 / 01期
关键词
D O I
暂无
中图分类号
R36 [病理学];
学科分类号
100104 ;
摘要
We have reported that gossypol, an antifertility agent, and gossypolone, a major metabolite of gossypol, inhibited steroidogenesis in bovine luteal cells in vitro. In the current study, the effects of these two compounds on steroidogenesis were examined in adrenocortical cells of young rats. ACTH-induced corticosterone secretion and intracellular adenosine monophosphate (cAMP) formation were significantly inhibited by gossypol at concentrations of 8.6 and 4.3-mu-M, respectively, and by gossypolone at concentrations of 8.6 and 4.3-mu-M, respectively. The present study demonstrated that both compounds inhibit ACTH-induced corticosterone synthesis and secretion in rat adrenocortical cell and this inhibition is, at least partially, attributed to the reduction of intracellular cAMP formation. Our data suggest that gossypol and its metabolite(s) probably affect steroidogenesis not only in gonads but also in adrenal glands by a common mean-reduction of intracellular cAMP.
引用
收藏
页码:27 / 38
页数:12
相关论文
共 50 条
[41]   Changes in adrenocorticotropic hormone (ACTH) release from the cultured anterior pituitary cells of Streptozotocin-induced diabetic rats [J].
Gohshi, A ;
Honda, K ;
Tominaga, K ;
Takano, Y ;
Motoya, T ;
Yamada, K ;
Kamiya, H .
BIOLOGICAL & PHARMACEUTICAL BULLETIN, 1998, 21 (08) :795-799
[42]   Direct effects of IL-15 on corticosterone secretion by rat adrenocortical cells [J].
Lo, MJ ;
Lee, SD .
IMMUNOLOGY AND CELL BIOLOGY, 2006, 84 (01) :38-43
[43]   A POSSIBLE INVOLVEMENT OF VIP IN FEEDING-INDUCED SECRETION OF ACTH AND CORTICOSTERONE IN THE RAT [J].
ALEXANDER, LD ;
EVANS, K ;
SANDER, LD .
PHYSIOLOGY & BEHAVIOR, 1995, 58 (02) :409-413
[44]   ADENOSINE REGULATES THE RELEASE OF ADRENOCORTICOTROPIC HORMONE (ACTH) FROM CULTURED ANTERIOR-PITUITARY CELLS [J].
ANANDSRIVASTAVA, MB ;
CANTIN, M ;
GUTKOWSKA, J .
MOLECULAR AND CELLULAR BIOCHEMISTRY, 1989, 89 (01) :21-28
[45]   Direct action of parathyroid hormone-related peptide to enhance corticosterone production stimulated by adrenocorticotropic hormone in adrenocortical cells of hens [J].
Kawashima, M ;
Takahashi, T ;
Yanai, H ;
Ogawa, H ;
Yasuoka, T .
POULTRY SCIENCE, 2005, 84 (09) :1463-1469
[46]   EFFECT OF LOVASTATIN ON THE INTERACTION BETWEEN HIGH-DENSITY-LIPOPROTEIN AND CULTURED RAT ADRENOCORTICAL-CELLS [J].
SVIRIDOV, D ;
FIDGE, N ;
REPIN, V ;
SMIRNOV, V .
ATHEROSCLEROSIS, 1991, 88 (2-3) :235-242
[47]   INDUCTION OF CORTICOSTEROID BIOSYNTHETIC-PATHWAY BY ACTH AND HIGH-DENSITY-LIPOPROTEIN IN NEWBORN RAT ADRENOCORTICAL-CELLS CULTURED IN SERUM-FREE MEDIUM [J].
HAMMAMI, M ;
LEGENDRE, C ;
MAUME, BF .
BIOCHIMICA ET BIOPHYSICA ACTA, 1986, 886 (03) :457-467
[48]   Effects of adrenomedullin and its fragment 22-52 on basal and ACTH-stimulated secretion of cultured rat adrenocortical cells [J].
Ziolkowska, A ;
Budzynska, K ;
Trejter, M ;
Tortorella, C ;
Belloni, AS ;
Malendowicz, LK .
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 2003, 11 (05) :613-615
[49]   OPTIMIZING ACTH-STIMULATED STEROID-SECRETION BY CULTURED ADRENOCORTICAL TUMOR-CELLS [J].
MATHIAS, S ;
WEI, L ;
HUNTER, E ;
WELLS, O ;
MGBONYEBI, O ;
MROTEK, J .
ENDOCRINE RESEARCH, 1995, 21 (1-2) :121-127
[50]   THE EFFECT OF LOW-DENSITY AND HIGH-DENSITY LIPOPROTEIN CHOLESTEROL ON STEROID-HORMONE PRODUCTION AND ACTH-INDUCED DIFFERENTIATION OF RAT ADRENOCORTICAL-CELLS IN PRIMARY CULTURE [J].
HEIKKILA, P ;
KAHRI, AI ;
EHNHOLM, C ;
KOVANEN, PT .
CELL AND TISSUE RESEARCH, 1989, 256 (03) :487-494