STRATEGY FOR ANALYZING THE COOPERATIVITY OF INTRAMOLECULAR INTERACTIONS IN PEPTIDES AND PROTEINS

被引：318

作者：

HOROVITZ, A

FERSHT, AR

机构：

[1] MRC Unit for Protein Function, Design Department of Chemistry, Cambridge, CB2 1EW, University Cambridge Lensfield Road

来源：

JOURNAL OF MOLECULAR BIOLOGY | 1990年 / 214卷 / 03期

关键词：

D O I：

10.1016/0022-2836(90)90275-Q

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Double mutant cycles enable the measurement of pairwise interactions in proteins. This method is extended for mutations at any number of positions in the protein. This provides a way for determining the context dependence of pairwise interactions on other neighbouring residues. © 1990.

引用

页码：613 / 617

页数：5

共 11 条

[1] EFFECTS OF SITE-SPECIFIC AMINO-ACID MODIFICATION ON PROTEIN INTERACTIONS AND BIOLOGICAL FUNCTION
ACKERS, GK
SMITH, FR
[J]. ANNUAL REVIEW OF BIOCHEMISTRY, 1985, 54 : 597 - 629
[2] PROTEIN STABILITY CURVES
BECKTEL, WJ
SCHELLMAN, JA
[J]. BIOPOLYMERS, 1987, 26 (11) : 1859 - 1877
[3] THE USE OF DOUBLE MUTANTS TO DETECT STRUCTURAL-CHANGES IN THE ACTIVE-SITE OF THE TYROSYL-TRANSFER RNA-SYNTHETASE (BACILLUS-STEAROTHERMOPHILUS)
CARTER, PJ
WINTER, G
WILKINSON, AJ
FERSHT, AR
[J]. CELL, 1984, 38 (03) : 835 - 840
[4] STATISTICAL GEOMETRY IN SEQUENCE SPACE - A METHOD OF QUANTITATIVE COMPARATIVE SEQUENCE-ANALYSIS
EIGEN, M
WINKLEROSWATITSCH, R
DRESS, A
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (16) : 5913 - 5917
[5] STRUCTURE-ACTIVITY-RELATIONSHIPS IN ENGINEERED PROTEINS - ANALYSIS OF USE OF BINDING-ENERGY BY LINEAR FREE-ENERGY RELATIONSHIPS
FERSHT, AR
LEATHERBARROW, RJ
WELLS, TNC
[J]. BIOCHEMISTRY, 1987, 26 (19) : 6030 - 6038
[6] NONADDITIVITY IN PROTEIN-PROTEIN INTERACTIONS
HOROVITZ, A
[J]. JOURNAL OF MOLECULAR BIOLOGY, 1987, 196 (03) : 733 - 735
[7] SYNERGISM IN FOLDING OF A DOUBLE MUTANT OF THE ALPHA-SUBUNIT OF TRYPTOPHAN SYNTHASE
HURLE, MR
TWEEDY, NB
MATTHEWS, CR
[J]. BIOCHEMISTRY, 1986, 25 (21) : 6356 - 6360
[8] HELIX STABILIZATION BY GLU- ... LYS+ SALT BRIDGES IN SHORT PEPTIDES OF DENOVO DESIGN
MARQUSEE, S
BALDWIN, RL
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (24) : 8898 - 8902
[9] POSITIONAL INDEPENDENCE AND ADDITIVITY OF AMINO-ACID REPLACEMENTS ON HELIX STABILITY IN MONOMERIC PEPTIDES
MERUTKA, G
STELLWAGEN, E
[J]. BIOCHEMISTRY, 1990, 29 (04) : 894 - 898
[10] LONG-RANGE ELECTROSTATIC INTERACTIONS CAN INFLUENCE THE FOLDING, STABILITY, AND COOPERATIVITY OF DIHYDROFOLATE-REDUCTASE
PERRY, KM
ONUFFER, JJ
GITTELMAN, MS
BARMAT, L
MATTHEWS, CR
[J]. BIOCHEMISTRY, 1989, 28 (19) : 7961 - 7968

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