STRATEGY FOR ANALYZING THE COOPERATIVITY OF INTRAMOLECULAR INTERACTIONS IN PEPTIDES AND PROTEINS

被引：318

作者：

HOROVITZ, A

FERSHT, AR

机构：

[1] MRC Unit for Protein Function, Design Department of Chemistry, Cambridge, CB2 1EW, University Cambridge Lensfield Road

来源：

JOURNAL OF MOLECULAR BIOLOGY | 1990年 / 214卷 / 03期

关键词：

D O I：

10.1016/0022-2836(90)90275-Q

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Double mutant cycles enable the measurement of pairwise interactions in proteins. This method is extended for mutations at any number of positions in the protein. This provides a way for determining the context dependence of pairwise interactions on other neighbouring residues. © 1990.

引用

页码：613 / 617

页数：5

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