TGF-BETA-RECEPTOR-MEDIATED SIGNALING

被引：280
作者：
DERYNCK, R
机构：
[1] UNIV CALIF SAN FRANCISCO, DEPT ANAT, SAN FRANCISCO, CA 94143 USA
[2] UNIV CALIF SAN FRANCISCO, CELL BIOL PROGRAM, SAN FRANCISCO, CA 94143 USA
[3] UNIV CALIF SAN FRANCISCO, PROGRAM DEV BIOL, SAN FRANCISCO, CA 94143 USA
来源：
TRENDS IN BIOCHEMICAL SCIENCES | 1994年 / 19卷 / 12期
关键词：
D O I：
10.1016/0968-0004(94)90059-0
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Transforming growth factor beta (TGF-beta) and its many relatives are thought to play key roles in the control of cell proliferation and differentiation. In particular, the ability of TGF-beta to induce growth arrest in epithelial cells has drawn considerable attention. The recent cloning of TGF-beta receptors, which are considered to be prototypes of a new class of cell-surface receptors, has provided a first insight into how TGF-beta signaling induces a variety of intracellular changes. Furthermore, recent advances in the characterization of the cell-cycle machinery have stimulated studies aimed at understanding how TGF-beta signaling leads to growth arrest in the late G1 phase of the cell cycle.
引用
收藏
页码：548 / 553
页数：6
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