PREVENTION OF DUODENAL-ULCER RELAPSE WITH AMOXICILLIN AND OMEPRAZOLE

被引：14

作者：

SPINZI, GC

SANGIOVANNI, A

IMPERIALI, G

TERRUZZI, V

MINOLI, G

BARATELLI, G

POSCA, M

SCARPIS, M

SNIDER, L

机构：

[1] Division of Medicine, Valduce Hospital, Como

[2] Division of Surgery, Gravedona Hospital, Como

[3] Division of Medicine, Erba Hospital, Como

[4] Division of Surgery, Menaggio Hospital, Como

[5] Division of Medicine, S. Anna Hospital, Como

来源：

EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY | 1994年 / 6卷 / 07期

关键词：

OMEPRAZOLE; HELICOBACTER-PYLORI; DUODENAL ULCER;

D O I：

10.1097/00042737-199407000-00006

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Objective: To evaluate, prospectively, whether omeprazole and amoxycillin eradicate Helicobacter pylori and prevent duodenal ulcer relapse. Patients and methods: This prospective multicentre trial included 53 patients. Twenty-nine H. pylori-positive patients were treated with omeprazole for 4 weeks (group A) and the remaining 24 received amoxycillin 'plus' omeprazole for 2 weeks. Eradication of H. pylori was evaluated using the rapid urease test and histological examination. Results: Six months after the end of therapy, H. pylori was eradicated in two out of 23 patients (9%) from group A and 10 out of 21 (48%) from group B. The ulcer relapse rate was 68% (n = 15) for patients from group A and 17% (n = 3) for those from group B. Conclusions: Our regimen eradicated H. pylori in half of our patients and is effective in preventing ulcer relapse with few adverse events.

引用

页码：599 / 602

页数：4

共 28 条

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