ROLE OF RADIATION IN THE MANAGEMENT OF ADULT PATIENTS WITH SARCOMA OF SOFT-TISSUE

被引:53
作者
SUIT, HD
SPIRO, I
机构
[1] Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts
来源
SEMINARS IN SURGICAL ONCOLOGY | 1994年 / 10卷 / 05期
关键词
SARCOMA; SOFT TISSUES; RADIATION THERAPY; LOCAL CONTROL; PREOPERATIVE;
D O I
10.1002/ssu.2980100507
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Radiation in moderate dose levels, viz. 60-65 Gy at 2 Gy/fraction, administered in combination with conservative surgery, yields local control frequencies at least comparable to those achieved by radical resectional surgery alone. The clinical interest in this management strategy is the reduction in the scope of the resection and a consequent gain in cosmetic and functional status. This combined approach is favored for sarcomas so situated that resection with wide margin, greater-than-or-equal-to 2 cm at the most narrow, cannot be realized unless there is a clinically important loss in function. Where radical surgery is planned, there must be great care in assessment of the probability of achieving good margins. The patient is ill served if there is radical surgery and then, because of close margins, postoperative radiation is required. There appears to be clinical gain for the patient with a large sarcoma by administering the radiation preoperatively. Advantages include smaller treatment volume and higher local control rates. The management of the surgical wound in the irradiated patient is discussed. Also, brief consideration is given to current use of brachytherapy, high linear energy transfer (LET) radiation, and combination of radiation and chemotherapy. (C) 1994 Wiley-Liss, Inc.
引用
收藏
页码:347 / 356
页数:10
相关论文
共 50 条
  • [31] Neoadjuvant chemotherapy for radiation-associated soft-tissue sarcoma: A case report
    Patel, Ronak
    Hu, James
    Chopra, Shefali
    Lee, Christopher
    RARE TUMORS, 2019, 11
  • [32] Imaging Soft-tissue Sarcomas of the Head and Neck: A Tertiary Soft-tissue Sarcoma Unit Experience
    Jaly, Alaa Alsadik
    Thway, Khin
    Touska, Philip
    Wale, Anita
    Miah, Aisha
    Kerawala, Cyrus
    Riva, Francesco
    Moskovic, Eleanor
    Jones, Robin L.
    Strauss, Dirk
    Dafydd, Derfel A. P.
    Messiou, Christina
    ANTICANCER RESEARCH, 2019, 39 (11) : 6223 - 6230
  • [33] DNA CONTENT AS A PREDICTOR OF CLINICAL OUTCOME IN SOFT-TISSUE SARCOMA PATIENTS
    BUDACH, W
    BUDACH, V
    SOCHA, B
    STUSCHKE, M
    STREFFER, C
    SACK, H
    EUROPEAN JOURNAL OF CANCER, 1994, 30A (12) : 1815 - 1821
  • [34] Chemotherapy options for patients with advanced soft-tissue sarcoma beyond anthracyclines
    Italiano, A.
    Toulmonde, M.
    Bui-Nguyen, B.
    BULLETIN DU CANCER, 2010, 97 (06) : 679 - 686
  • [35] Targeted Chemotherapy in Bone and Soft-Tissue Sarcoma
    Harwood, Jared L.
    Alexander, John H.
    Mayerson, Joel L.
    Scharschmidt, Thomas J.
    ORTHOPEDIC CLINICS OF NORTH AMERICA, 2015, 46 (04) : 587 - +
  • [36] Neoadjuvant or Adjuvant Chemotherapy in Soft-Tissue Sarcoma?
    Piotr Remiszewski
    Kinga Filipek
    Agata Pisklak
    Paulina Chmiel
    Piotr Rutkowski
    Anna M. Czarnecka
    Current Oncology Reports, 2025, 27 (5) : 491 - 515
  • [37] EDATREXATE IN PATIENTS WITH SOFT-TISSUE SARCOMA - ACTIVITY IN MALIGNANT FIBROUS HISTIOCYTOMA
    CASPER, ES
    CHRISTMAN, KL
    SCHWARTZ, GK
    JOHNSON, B
    BRENNAN, MF
    BERTINO, JR
    CANCER, 1993, 72 (03) : 766 - 770
  • [38] Recent advances in radiotherapy for soft-tissue sarcoma
    Brian O’sullivan
    Iain Ward
    Charles Catton
    Current Oncology Reports, 2003, 5 (4) : 274 - 281
  • [39] Is There Value in Molecular Profiling of Soft-Tissue Sarcoma?
    Italiano, Antoine
    CURRENT TREATMENT OPTIONS IN ONCOLOGY, 2018, 19 (12)
  • [40] A multidisciplinary approach to soft-tissue sarcoma of the extremities
    Nakayama, Robert
    Mori, Tomoaki
    Okita, Yusuke
    Shiraishi, Yutaka
    Endo, Makoto
    EXPERT REVIEW OF ANTICANCER THERAPY, 2020, 20 (10) : 893 - 900